Harnessing miRNA from Human Embryonic Stem Cells to Rejuvenate Aging Cells and Extend Healthspan

Exosomes Rejuvenate Aging Cells

New Stem Cell Study

(Provided by KS Kim/Stock)

In a groundbreaking study published in Cell Metabolism, researchers investigated the potential of microRNA (miRNA) derived from exosomes generated by human embryonic stem cells (hESCs) to combat cellular senescence. This innovative approach demonstrated promising results in cell cultures and murine models, suggesting a potential pathway to rejuvenate aging tissues and extend health span.

Understanding Cellular Senescence

Cellular senescence is when cells lose their ability to divide and function properly. It plays a complex role in aging: while it can prevent the proliferation of damaged cells, an accumulation of senescent cells contributes to age-related decline and chronic inflammation. Traditional approaches to address senescence include:

• Senolytics: These drugs aim to eliminate senescent cells selectively but may carry risks due to their side effects.
• Senomorphics: These strategies attempt to modify the behavior of senescent cells to mitigate their harmful effects.